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It looks like this particular product contains just b-vitamins, calcium, C and E, so it falls short of being considered a multi-vitamin and mineral. View abstract. Indian J.Dermatol.Venereol.Leprol. Chen, F., Ding, M., Castranova, V., and Shi, X. Carcinogenic metals and NF-kappaB activation. Pneumologie 1990;44 Suppl 1:397-398. View abstract. Int.J.Environ.Health Res. An international literature survey of "IARC Group I carcinogens" reported in mainstream cigarette smoke. Kuper, C. F., Woutersen, R. A., Slootweg, P. J., and Feron, V. J. Carcinogenic response of the nasal cavity to inhaled chemical mixtures. Apostoli, P. and Catalani, S. [Mechanisms of action for metallic elements and their species classified carcinogen R 45 and R 49 by EU]. Occup.Environ.Med. Health risks associated with inhaled nasal toxicants. View abstract. 1990;52(3):3-8. Contact Dermatitis 2007;57(5):287-299. View abstract. Saudi.Med.J. 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I applaud that Europe specifies L-ascorbate on their labels, that is the source of vitamin C you want. Human stratum corneum adsorption of nickel salts. Free Radic.Biol.Med. But there are other foods, like meats, eggs and citrus fruits that are lower in nickel, but higher in B vitamins. Nikula, K. J. and Green, F. H. Animal models of chronic bronchitis and their relevance to studies of particle-induced disease. J.Toxicol.Clin.Toxicol. 1984;179(6):427-431. Cancer Causes Control 2007;18(1):7-27. Kasprzak, K. S., Bal, W., and Karaczyn, A. 2006;18(12):1001-1004. View abstract. Valko, M., Rhodes, C. J., Moncol, J., Izakovic, M., and Mazur, M. Free radicals, metals and antioxidants in oxidative stress-induced cancer. View abstract. Fischer, A. 1990;18(2):83-88. View abstract. Herfs, H., Schirren, C. G., Przybilla, B., and Plewig, G. ["Baboon syndrome". Costa, M., Sutherland, J. E., Peng, W., Salnikow, K., Broday, L., and Kluz, T. Molecular biology of nickel carcinogenesis. 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Wingren, G. and Axelson, O. Epidemiologic studies of occupational cancer as related to complex mixtures of trace elements in the art glass industry. View abstract. Tossavainen, A. IARC Sci.Publ. A. and Cabelli, D. E. Superoxide dismutases-a review of the metal-associated mechanistic variations. Clin.Physiol Biochem. View abstract. 2006;63(5):365-366. Often, it is grown as a potherb in the backyard so that its fresh leaves and flowers can bereadily harvested for immediate use. Occup.Environ.Med. View abstract. Toxicology 4-15-2005;209(2):119-121. View abstract. 1984;(53):469-485. Regul Toxicol Pharmacol 2005;43:117-33. Norseth, T. Epidemiological approach to nickel carcinogenicity--uses and limitation. 1984;179(6):427-431. View abstract. Taking amounts slightly above the 1 mg/day level increases the chances of unwanted side effects. Beyersmann, D. Interactions in metal carcinogenicity. Le, Gales C. and Oudiz, A. Costa, M., Salnikow, K., Sutherland, J. E., Broday, L., Peng, W., Zhang, Q., and Kluz, T. The role of oxidative stress in nickel and chromate genotoxicity. View abstract. View abstract. 5-24-1998;139(21):1297-1302. Buzard, G. S. and Kasprzak, K. S. Possible roles of nitric oxide and redox cell signaling in metal-induced toxicity and carcinogenesis: a review. Boffetta, P., Cardis, E., Vainio, H., Coleman, M. P., Kogevinas, M., Nordberg, G., Parkin, D. M., Partensky, C., Shuker, D., and Tomatis, L. Cancer risks related to electricity production. Z.Lebensm.Unters.Forsch. Sunderman, J. W., Jr. A review of the carcinogenicities of nickel, chromium and arsenic compounds in man and animals. Chiu, A., Katz, A. J., Beaubier, J., Chiu, N., and Shi, X. Scand.J.Work Environ.Health 1993;19 Suppl 1:95-100. Gottschall, E. B. 1983;13(1):1-4. View abstract. Santamaria Babi, L. F., Perez Soler, M. T., Hauser, C., and Blaser, K. Skin-homing T cells in human cutaneous allergic inflammation. View abstract. Antioxid.Redox.Signal. View abstract. Grimsrud, T. K. and Peto, J. Persisting risk of nickel related lung cancer and nasal cancer among Clydach refiners. It's important to take fruits rich in vitamin C to counteract the effect of nickel in our body. Wild, P., Bourgkard, E., and Paris, C. Lung cancer and exposure to metals: the epidemiological evidence. View abstract. Contact dermatitis to metals. Ann.Clin.Lab Sci 2001;31(1):3-24. Nickel is everywhere, but now you can test for nickel before your skin does with Nickel Alert® ! Children: Nickel is LIKELY SAFE in children in daily doses less than the tolerable upper intake level (UL) of 0.2 mg/day in children 1 to 3 years, 0.3 mg/day in children 4 to 8 years, and 0.6 mg/day in children 9 to 13 years. Genetic and cellular mechanisms in chromium and nickel carcinogenesis considering epidemiologic findings. Health risks associated with inhaled nasal toxicants. Prev.Med. Allergol.Immunopathol.(Madr.) Nowak, D., Ochmann, U., Huber, R. M., and Diederich, S. 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But nickel can be found in many everyday items, such as coins, zippers, cellphones and eyeglass frames.It may take repeated or prolonged exposure to items containing nickel to develop a nickel allergy. One thing to note: It doesn’t contain … It features 100% of your daily value for many essential vitamins, including A, C, D, E and many of the B vitamins. Wish it wasn't so expensive, but so far a great product. View abstract. In vivo ultraviolet irradiation of human skin results in profound perturbation of the immune system. B. View abstract. View abstract. Mol.Cell Biochem. Nordberg, G. F. and Andersen, O. 6-1-1988;71(3):243-252. 2017 Nov/Dec;28(6):368. 2000;19(1-2):129-138. Maridet C, Atge B, Amici JM, Taïeb A, Milpied B. Spinach is also an excellent source of a multitude of vitamins and minerals such as vitamin K, vitamin A, calcium and potassium. View abstract. View abstract. J.Chromatogr.B Biomed.Sci.Appl. Other animal research has shown that nickel concentration influences the production of certain hormones, including adrenaline … View abstract. 1998;157:53-94. Distribution of cobalt chromium wear and corrosion products and biologic reactions. 12-10-2003;533(1-2):67-97. B. and Moller, H. Release of nickel from cooking utensils. View abstract. 2003;24(11):1176-1182. Bal, W., Kozlowski, H., and Kasprzak, K. S. Molecular models in nickel carcinogenesis. Pol.Merkur Lekarski. View abstract. J Environ Monit 2004;6:146N-150N. View abstract. View abstract. 1984;30(5):259-263. View abstract. Toxicol.Appl.Pharmacol. Am.J.Epidemiol. Pharmacol.Ther. The skin becomes inflamed and itchy, sometimes even with watery blisters, after not more then twenty minutes of the exposure to things that contain nickel. Nieboer, E., Rossetto, F. E., and Turnbull, J. D. Molecular biology approaches to biological monitoring of genotoxic substances. View abstract. Sangyo Igaku 1993;35(2):75-87. Nickel oral hyposensitization in patients with systemic nickel allergy syndrome. Foods High in Nickel. 1984;(53):95-103. 1989;13(2):205-216. 12-30-2005;592(1-2):79-88. Therapeutic properties of sodium diethyldithiocarbamate: its role as an inhibitor in the progression of AIDS. Trumbo, P., Yates, A. Laffargue, P., Hildebrand, H. F., Lecomte-Houcke, M., Biehl, V., Breme, J., and Decoulx, J. Acta Derm.Venereol.Suppl (Stockh) 2001;(212):19-23. Reger, R. B. and Morgan, W. K. Respiratory cancers in mining. J.Oral Rehabil. Agency for Toxic Substances and Disease Registry. View abstract. Mol.Cell Biochem. J.Hyg.Epidemiol.Microbiol.Immunol. 1998;201(Pt 8):1197-1201. Curr.Opin.Allergy Clin.Immunol. Domingo, J. L. Metal-induced developmental toxicity in mammals: a review. 2002;110 Suppl 4:505-526. View abstract. Metal interactions in carcinogenesis: enhancement, inhibition. Seilkop SK, Oller AR. Mutat.Res. View abstract. The role of chromatin damage in nickel-induced carcinogenesis. View abstract. Ann.Occup.Hyg. View abstract. This survey is being conducted by the WebMD marketing sciences department. Available at: www.nap.edu/books/0309072794/html/. Costa, M. and Heck, J. D. Perspectives on the mechanism of nickel carcinogenesis. View abstract. View abstract. Ward, J. J., Thornbury, D. D., Lemons, J. E., and Dunham, W. K. Metal-induced sarcoma. View abstract. J Investig Allergol Clin Immunol. View abstract. View abstract. 2008;125(1):1-12. IARC Sci.Publ. Indian J.Med.Res. 2004;3(1):29-35. Investigation of depth profiles by tape stripping in vivo. Laffargue, P., Hildebrand, H. F., Lecomte-Houcke, M., Biehl, V., Breme, J., and Decoulx, J. Am.Rev.Respir.Dis. van der Voet, G. B., Sarafanov, A., Todorov, T. I., Centeno, J. Slotkin, T. A. and Seidler, F. J. Oxidative and excitatory mechanisms of developmental neurotoxicity: transcriptional profiles for chlorpyrifos, diazinon, dieldrin, and divalent nickel in PC12 cells. Nickel is a common trace element in multiple vitamins. Sivulka DJ. Cashews. IARC Sci.Publ. 1990;(104):363-367. Sunderman, F. W., Jr. Mechanistic aspects of nickel carcinogenicity. Lund, V. J. Malignancy of the nose and sinuses. 1994;102(4):398-401. Nickel, chromium and cobalt in consumer products: revisiting safe levels in the new millennium. Leikauf, G. D. Hazardous air pollutants and asthma. Kielhorn, J., Melber, C., Keller, D., and Mangelsdorf, I. Palladium--a review of exposure and effects to human health. View abstract. View abstract. Mutat.Res. View abstract. Truly a eureka moment View abstract. van der Voet, G. B., Sarafanov, A., Todorov, T. I., Centeno, J. Johnson, W., Jr. Metal interactions in carcinogenesis: enhancement, inhibition. Verougstraete, V., Lison, D., and Hotz, P. Cadmium, lung and prostate cancer: a systematic review of recent epidemiological data. Int.J.Toxicol. Toxicol.Lett. 2008;125(1):1-12. 11-1-1995;134(21):679-680. These people should not take nickel supplements. Animal models of malignant mesothelioma. Bostrom, C. E., Almen, J., Steen, B., and Westerholm, R. Human exposure to urban air pollution. Faroon, O. M., Williams, M., and O'Connor, R. A review of the carcinogenicity of chemicals most frequently found at National Priorities List sites. View abstract. View abstract. Przegl.Lek. Shen, H. M. and Zhang, Q. F. Risk assessment of nickel carcinogenicity and occupational lung cancer. View abstract. 2001;38:289-311. 1991;127(1):99-109. WebMD does not provide medical advice, diagnosis or treatment. 1989;21:459-467. Report of the International Committee on Nickel Carcinogenesis in Man. The FDA should take the responsibility to conduct investigations and make reports of some herbal supplements’ possible side effects. View abstract. Semin.Respir.Crit Care Med. Expert.Rev.Med.Devices 2010;7(4):489-501. Wild, P., Bourgkard, E., and Paris, C. Lung cancer and exposure to metals: the epidemiological evidence. Cavani, A., Ottaviani, C., Nasorri, F., Sebastiani, S., and Girolomoni, G. Immunoregulation of hapten and drug induced immune reactions. These people should not take nickel supplements. 1991;21(1):70-81. The epidemiology of lung cancer. A review of recent developments. View abstract. View abstract. Methods Mol.Biol. Clinical effect of Fuzheng Jiedu granule on serum NO, NOS and microelements in patients with coronary heart disease in long-term contact with nickel. Clin.Orthop.Relat Res. Villanueva, S. F. and Botello, A. V. Metal pollution in coastal areas of Mexico. Z.Lebensm.Unters.Forsch. View abstract. Pneumologie 2005;59(3):178-191. Safe upper levels for vitamins and minerals. 2009;117(4):587-596. 2002;383(6):961-967. Use of XAS for the elucidation of metal structure and function: applications to nickel biochemistry, molecular toxicology, and carcinogenesis. IARC Sci.Publ. 1994;178(1):57-66. Costa, M. Molecular mechanisms of nickel carcinogenesis. J.Clin.Oncol. Taking higher doses is POSSIBLY UNSAFE. Morphol.Igazsagugyi Orv.Sz 1988;28(2):95-110. However, boron and nickel are found in many foods, and tin is sometimes used as an inactive ingredient in tablets. 2009;472:3-23. View abstract. Sci.Total Environ. Baadsgaard, O. View abstract. View abstract. Boffetta, P. Carcinogenicity of trace elements with reference to evaluations made by the International Agency for Research on Cancer. Waalkes, M. P., Coogan, T. P., and Barter, R. A. Toxicological principles of metal carcinogenesis with special emphasis on cadmium. View abstract. Sunderman, F. W., Jr. Nickel carcinogenesis. Crit Rev.Toxicol. View abstract. Kasprzak, K. S., Sunderman, F. W., Jr., and Salnikow, K. Nickel carcinogenesis. 1997;386(2):163-180. Leonard, A. and Jacquet, P. Embryotoxicity and genotoxicity of nickel. Baccarelli, A. and Bollati, V. Epigenetics and environmental chemicals. J.Invest Dermatol. May 2003; pages 225-31. View abstract. View abstract. View abstract. Other Vitamins and Minerals. View abstract. Immunol.Res. View abstract. Dermatol.Clin. EXS 2006;(96):97-130. 1996;23(5):309-320. View abstract. Potential toxicity from nickel contamination of intravenous fluids. 1991;127(1):99-109. View abstract. In vitro toxicology of heavy metals using mammalian cells: an overview of collaborative research data. View abstract. Disulfiram and low nickel diet in the management of hand eczema: a clinical study. View abstract. View abstract. View abstract. Hostynek, J. J. Sensitization to nickel: etiology, epidemiology, immune reactions, prevention, and therapy. Nijhawan, R. I., Molenda, M., Zirwas, M. J., and Jacob, S. E. Systemic contact dermatitis. Kilburn, K. H. Function testing for chemical brain damage: a review. Templeton, D. M., Sunderman, F. W., Jr., and Herber, R. F. Tentative reference values for nickel concentrations in human serum, plasma, blood, and urine: evaluation according to the TRACY protocol. Johnson, W., Jr. 2003;5(2):222-223. View abstract. View abstract. Many foods higher in magnesium, like spinach, nuts, figs, legumes and chocolate, are also higher in nickel. Regul Toxicol Pharmacol 2003;37:173-90. View abstract. Eur Respir.J 1990;3(2):202-219. Setcos JC, Babaei-Mahani A, Silvio LD, et al. Nordberg, G. F. Current concepts in the assessment of effects of metals in chronic low-level exposures--considerations of experimental and epidemiological evidence.